Linked Life Data

3193208

Source:http://linkedlifedata.com/resource/pubmed/id/3193208

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1989-1-12
pubmed:abstractText
The relation between the externally measured myocardial time-activity curve and the radiochemically determined kinetics of iodine-131(131I) heptadecanoic acid was studied in an open-chest canine model under different metabolic interventions. Kinetics were assessed by analysis of 12 biopsies taken in an assay period of 90 min. Time-activity curves were fitted with a monoexponential plus constant. The halftime value of the exponential of the external curve corresponded well with the elimination rate of 131I from the myocardium: 14.6 +/- 4.5 min vs. 14.6 +/- 5.3 min. The constant was build up of three components: free 131I in cardiac tissue, the almost constant activity of the radiolabeled free fatty acid (FFA) in the myocardial lipid pool, and the radioactivity of blood and noncardiac tissues. The contribution of blood and noncardiac tissue to the constant amounted to a mean value of 77%. These findings support the analysis of externally measured time-activity curves with a monoexponential plus constant curve fit, in which background correction is not necessary. In cases where lipid storage is predominantly present, high T1/2 values, both internally and externally, were found, which were fitted with a monoexponential curve. It can be concluded that externally measured time-activity curves reflect satisfactorily the kinetics of radioiodinated heptadecanoic acid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0161-5505
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1934-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Comparison of 17-iodine-131 heptadecanoic acid kinetics from externally measured time-activity curves and from serial myocardial biopsies in an open-chest canine model.
pubmed:affiliation
Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study