| pubmed-article:3177660 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3177660 | lifeskim:mentions | umls-concept:C1705597 | lld:lifeskim |
| pubmed-article:3177660 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:3177660 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:3177660 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:3177660 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:3177660 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3177660 | lifeskim:mentions | umls-concept:C0033713 | lld:lifeskim |
| pubmed-article:3177660 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:3177660 | pubmed:issue | 4 Pt 2 | lld:pubmed |
| pubmed-article:3177660 | pubmed:dateCreated | 1988-11-9 | lld:pubmed |
| pubmed-article:3177660 | pubmed:abstractText | Nontransformed monkey kidney cells (BSC-1 line), used as a model for renal epithelium, were assayed for release of platelet-derived growth factor (PDGF)-like proteins. BSC-1 cells continuously released a mitogenic activity for fibroblasts and a chemoattractant activity for smooth muscle cells, each of which was inhibited 80-90% by an antibody to human PDGF. A cDNA probe for the PDGF B-chain gene (c-sis), but not for the A-chain gene, hybridized to mRNA obtained from growing and quiescent cells. c-sis gene expression and PDGF-like protein secretion were studied in the presence of known growth-regulatory molecules. A secreted BSC-1 cell protein identical to transforming growth factor beta 2 inhibited DNA synthesis in growing cultures and induced marked accumulation of c-sis mRNA without a corresponding increase in the release of PDGF-like activity. Adenosine diphosphate stimulated DNA synthesis in quiescent cultures and enhanced both c-sis expression and release of PDGF-like activity. However, growing and quiescent cells did not express the PDGF receptor gene or exhibit a mitogenic response to authentic PDGF. Thus the PDGF-like protein released by these kidney epithelial cells could contribute to growth control by a paracrine mechanism. | lld:pubmed |
| pubmed-article:3177660 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3177660 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3177660 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3177660 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3177660 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3177660 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3177660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3177660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3177660 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3177660 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3177660 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:3177660 | pubmed:author | pubmed-author:TobackF GFG | lld:pubmed |
| pubmed-article:3177660 | pubmed:author | pubmed-author:KarthaSS | lld:pubmed |
| pubmed-article:3177660 | pubmed:author | pubmed-author:GrotendorstG... | lld:pubmed |
| pubmed-article:3177660 | pubmed:author | pubmed-author:BradhamD MDM | lld:pubmed |
| pubmed-article:3177660 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3177660 | pubmed:volume | 255 | lld:pubmed |
| pubmed-article:3177660 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3177660 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3177660 | pubmed:pagination | F800-6 | lld:pubmed |
| pubmed-article:3177660 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:meshHeading | pubmed-meshheading:3177660-... | lld:pubmed |
| pubmed-article:3177660 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3177660 | pubmed:articleTitle | Kidney epithelial cells express c-sis protooncogene and secrete PDGF-like protein. | lld:pubmed |
| pubmed-article:3177660 | pubmed:affiliation | Department of Medicine, University of Chicago, Illinois 60637. | lld:pubmed |
| pubmed-article:3177660 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3177660 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3177660 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3177660 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3177660 | lld:pubmed |
