Linked Life Data

3176962

Source:http://linkedlifedata.com/resource/pubmed/id/3176962

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1988-11-23
pubmed:abstractText
Guinea pig tympanic membrane was anesthetized iontophoretically. The animals were sacrificed between 2 h and 4 days after the anesthesia and the tympanic membrane was studied histologically by light microscopy and transmission electron microscopy. Edema in the subepidermal connective tissue layer and detachment of the basement membrane from the basal cell layer were observed 2 h after iontophoresis. Eight and 12 h later, the epidermal layer between the handle of the malleus and the bony annulus peeled and retracted towards the bony annulus, leaving only hornified outer epidermis on the fibrous layer. Four days after iontophoresis, the retracted margin of the epidermal layer became greatly thickened and evidence of hyperplasia and migration was observed. This study has demonstrated that iontophoresis of the tympanic membrane produces remarkable histological changes. However, no perforation was observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0001-6489
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Short-term effects of iontophoresis on the structure of the guinea pig tympanic membrane.
pubmed:affiliation
Department of Otolaryngology, Chonnam University, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't