Linked Life Data

3162913

Source:http://linkedlifedata.com/resource/pubmed/id/3162913

Statements in which the resource exists.
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pubmed-article:3162913pubmed:abstractTextHuman transforming growth factor beta 1 (TGF-beta 1) was purified as a latent high Mr complex from human platelets by a six-step procedure. Analysis by sodium dodecyl sulfate (SDS)-gel electrophoresis under reducing conditions revealed that the complex was composed of at least three components with apparent Mr values of 13,000, 40,000, and 125,000-160,000. The 13-kDa subunit was part of a disulfide-bonded dimer and was identified by amino acid sequencing as TGF-beta 1. The 40-kDa subunit was identified as the amino-terminal part of the TGF-beta 1 precursor lacking the hydrophobic signal sequence. Partial sequencing of the 125-160-kDa protein revealed that it is distinct from known proteins. The 40-kDa and the 125-160-kDa subunits are linked by disulfide bonds, forming a complex with an apparent Mr of 210,000 on SDS gels under nonreducing conditions. Experiments with partial reduction revealed that each complex contains two 40-kDa components linked by disulfide bonds; in addition, the dimer is disulfide-linked to one 125-160-kDa binding protein. TGF-beta 1 binds noncovalently to the 210-kDa complex, and in bound form, TGF-beta 1 is inactive. Incubations of the latent form of TGF-beta 1 at extreme pH values, in 0.02% SDS or in 8 M urea, lead to activation of TGF-beta 1, whereas the complex was resistant to treatment with 5 M NaCl or heat (3 min at 95 degrees C).lld:pubmed
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pubmed-article:3162913pubmed:articleTitleLatent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.lld:pubmed
pubmed-article:3162913pubmed:affiliationLudwig Institute for Cancer Research, Uppsala, Sweden.lld:pubmed
pubmed-article:3162913pubmed:publicationTypeJournal Articlelld:pubmed
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