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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1988-12-20
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pubmed:abstractText |
Although Neisseria meningitidis does not produce siderophores, it is able to obtain iron from human transferrin. We observed saturable specific binding of 125I-labeled human transferrin to meningococci. Human lactoferrin and mouse transferrin did not compete with human transferrin for binding, whereas human apotransferrin and 100% iron-saturated transferrin competed equally well. Meningococci thus have a specific receptor for human transferrin. Scatchard analysis yielded a relatively low Kd of 0.7 microM and an apparent copy number of 2,900 receptors per CFU. Receptor activity was iron-regulated. A meningococcal transformant specifically unable to utilize transferrin as an iron source had decreased transferrin receptor activity. These data are consistent with the hypothesis that receptor-mediated binding of transferrin is a rate-limiting step in meningococcal iron uptake from transferrin.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-14047217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-14450081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-2849026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-2888836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3036550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3096888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3112120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3126143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3126152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3128478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3132585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3143887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3155708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-3546186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-379572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-406329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6088662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6159328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6210635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6293371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6429042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6455965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6758629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6790443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6795121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3141281-6809629
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3132-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
Loss of transferrin receptor activity in Neisseria meningitidis correlates with inability to use transferrin as an iron source.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill 27599.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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