Linked Life Data

3132607

Source:http://linkedlifedata.com/resource/pubmed/id/3132607

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-7-18
pubmed:abstractText
Inhibition of in vitro translation activity by the chemotherapeutic agent cisplatin has been studied. Peptide synthesis was measured in translation assays prepared from guinea pig and rabbit reticulocyte lysates. There is a concentration- and time-dependent inactivation of translation by cisplatin. Inhibition is nearly maximal after a 30-min exposure. Translation is inhibited by cisplatin at concentrations that have been found after the administration of therapeutic doses. Evidence suggests that the suppression of peptide synthesis is due to an interaction between cisplatin and mRNA. An apparent qualitative difference in the peptide products translated from mRNA exposed to cisplatin is demonstrated. Large peptide products are inhibited to a greater extent than products with faster electrophoretic mobility. Decreased translation activity cannot be explained by digestion of the message by either cisplatin itself or by some contaminant of the drug solution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0026-895X
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Messenger RNA loses the ability to direct in vitro peptide synthesis following incubation with cisplatin.
pubmed:affiliation
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824.
pubmed:publicationType
Journal Article