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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1988-5-12
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pubmed:abstractText |
The influence of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) and 1-hexadecylmercapto-2-methoxymethyl-rac-propyl-3-phosphocholine (TLP, BM41.440) on methylnitrosourea (MNU)-induced rat mammary carcinomas and of ET-18-OCH3 on 7,12-dimethylbenzanthracene (DMBA)-induced leukemias was investigated. Both agents effectively delayed MNU-induced mammary tumor formation at high, cytotoxic dosages but TLP had no influence at low "immunomodulatory" doses. ET-18-OCH3 also significantly protected against leukemia development in DMBA-treated Long-Evans rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/9,10-Dimethyl-1,2-benzanthracene,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Methylnitrosourea,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipid Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Acid Esters,
http://linkedlifedata.com/resource/pubmed/chemical/edelfosine,
http://linkedlifedata.com/resource/pubmed/chemical/ilmofosine
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0024-4201
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
935-42
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3127647-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:3127647-Administration, Oral,
pubmed-meshheading:3127647-Animals,
pubmed-meshheading:3127647-Antineoplastic Agents,
pubmed-meshheading:3127647-Dose-Response Relationship, Drug,
pubmed-meshheading:3127647-Female,
pubmed-meshheading:3127647-Leukemia, Experimental,
pubmed-meshheading:3127647-Lysophospholipids,
pubmed-meshheading:3127647-Male,
pubmed-meshheading:3127647-Mammary Neoplasms, Experimental,
pubmed-meshheading:3127647-Methylnitrosourea,
pubmed-meshheading:3127647-Neoplasms, Experimental,
pubmed-meshheading:3127647-Organophosphorus Compounds,
pubmed-meshheading:3127647-Phospholipid Ethers,
pubmed-meshheading:3127647-Phosphoric Acid Esters,
pubmed-meshheading:3127647-Rats,
pubmed-meshheading:3127647-Rats, Inbred Strains
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pubmed:year |
1987
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pubmed:articleTitle |
Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids.
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pubmed:affiliation |
Institute of Toxicology and Chemotherapy, German Cancer Research Institute, Heidelberg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article
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