| pubmed-article:3118413 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C0019010 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C0003695 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C0040060 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C0376618 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:3118413 | lifeskim:mentions | umls-concept:C1512045 | lld:lifeskim |
| pubmed-article:3118413 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3118413 | pubmed:dateCreated | 1987-11-27 | lld:pubmed |
| pubmed-article:3118413 | pubmed:abstractText | We investigated the effects of a new pyridoquinazoline thromboxane synthetase inhibitor infused before administering Escherichia Coli endotoxin into 18 anesthetized sheep with lung lymph fistulas. In normal sheep increasing plasma Ro 23-3423 concentrations were associated with increased plasma levels of 6-keto-PGF1 alpha, a reduced systemic vascular resistance (SVR, r = -0.80) and systemic arterial pressure (SAP, r = -0.92), the mean SAP falling from 80 to 50 mm Hg at the 20 and 30 mg/kg doses. Endotoxin infused into normal sheep caused transient pulmonary vasoconstriction associated with increased TxB2 and 6-keto-PGF1 alpha levels while vasoconstriction and TxB2 increase were significantly inhibited by pretreatment with Ro 23-3423 in a dose-dependent manner. When compared to controls, plasma and lymph levels of 6-keto-PGF1 alpha, PGF2 alpha and PGE2 after endotoxin infusion were increased several-fold by administering Ro 23-3423 up to plasma levels of 10 micrograms/ml. Doses over 30 mg/kg with blood levels above 10 micrograms/ml reduced plasma and lymph levels of 6-keto-PGF1 alpha, PGF2 alpha and PGE2, suggesting cyclooxygenase blockade at this dose. The peak 6-keto-PGF1 alpha levels at 60 min after endotoxin infusion in sheep with Ro-23-3423 levels below 10 micrograms/ml were associated with the greatest systemic hypotension due to a reduced SVR (r = -0.86). After endotoxin infusion the leukotrienes B4, C4, D4 and E4 in lung lymph were assayed by radioimmunoassay and high pressure liquid chromatography and remained at baseline values. | lld:pubmed |
| pubmed-article:3118413 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3118413 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3118413 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3118413 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3118413 | pubmed:issn | 0090-6980 | lld:pubmed |
| pubmed-article:3118413 | pubmed:author | pubmed-author:ZapolW MWM | lld:pubmed |
| pubmed-article:3118413 | pubmed:author | pubmed-author:RobinsonD RDR | lld:pubmed |
| pubmed-article:3118413 | pubmed:author | pubmed-author:MorelD RDR | lld:pubmed |
| pubmed-article:3118413 | pubmed:author | pubmed-author:SkoskiewiczM... | lld:pubmed |
| pubmed-article:3118413 | pubmed:author | pubmed-author:MelvinCC | lld:pubmed |
| pubmed-article:3118413 | pubmed:author | pubmed-author:HuttemeierP... | lld:pubmed |
| pubmed-article:3118413 | pubmed:author | pubmed-author:NguyenduyTT | lld:pubmed |
| pubmed-article:3118413 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3118413 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:3118413 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3118413 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3118413 | pubmed:pagination | 879-902 | lld:pubmed |
| pubmed-article:3118413 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:3118413 | pubmed:meshHeading | pubmed-meshheading:3118413-... | lld:pubmed |
| pubmed-article:3118413 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3118413 | pubmed:articleTitle | Dose-dependent effects of a pyridoquinazoline thromboxane synthetase inhibitor on arachidonic acid metabolites and hemodynamics during E. coli endotoxemia in anesthetized sheep. | lld:pubmed |
| pubmed-article:3118413 | pubmed:affiliation | Department of Anesthesia, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:3118413 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3118413 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3118413 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
