Linked Life Data

3113082

Source:http://linkedlifedata.com/resource/pubmed/id/3113082

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1987-8-28
pubmed:abstractText
The concept of a blood brain or blood tumour barrier blocking the passage of lipid insoluble cytoreductive drugs from blood into brain-tumor, leads to a protocol of intraarterial injection of high dose methotrexate (MTX) during reversible, osmotic blood brain barrier disruption (BBBD). Malignant Gliomas of grades III and IV in 9 patients and one primary CNS-lymphoma in one patient have been treated in 2 to 5 sessions per patient with BBBD plus polychemotherapy (MTX, cyclophosphamide, procarbazine). Median progression free intervals (PFI) which are still in continuation are 12.2 months. Median PFI which had been terminated by tumour recurrence are 7.75 months.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0043-5325
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
385-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Reversible opening of the blood-brain barrier in the chemotherapy of malignant gliomas].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't