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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1987-8-31
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pubmed:abstractText |
Deflazacort was substituted for Prednisone (based on the equivalence 1 mg Prednisone equals 1.2 mg Deflazacort), during maintenance glucocorticoid therapy in 9 children, 5 with renal diseases and 4 with connective tissue or immunoproliferative disorders. Six patients received 0.26-0.35 mg/kg body weight (B.W.)/day and 3 0.48-1.2 mg/kg B.W. on alternate days, for 10-16 months. Except for a child with chronic juvenile arthritis, who was also unresponsive to Prednisone, the therapeutic effects of Deflazacort were excellent. Steroid side effects present in 8 patients decreased or disappeared. Plasma Ca, P, Mg, creatinine, alkaline phosphatase, iPTH(1-34), urinary excretion of Ca, cAMP, and TRP remained normal. Plasma iPTH(1-84) remained normal in 5 children; in the other 4 patients it increased from normal to slightly elevated values. On Deflazacort, plasma calcidiol concentrations were within the normal range in 6/8 patients prescribed daily doses of vitamin D2 (1,600-2,400 IU) or calcidiol (20 micrograms). Plasma 1,25(OH)2D levels monitored in 5 children were also normal. The osteoporosis, evaluated on the tibial cortico-diaphyseal ratio and the trabecular aspect of bone radiograms, present in 5 patients, persisted in 1 and improved in the others. On Deflazacort, statural growth proceeded normally in all subjects, with a modest acceleration of growth velocity in 3 children. These results seem encouraging for extending clinical trials with Deflazacort to the active phase of pediatric diseases requiring glucocorticoid.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcifediol,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Minerals,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisone,
http://linkedlifedata.com/resource/pubmed/chemical/Pregnenediones,
http://linkedlifedata.com/resource/pubmed/chemical/deflazacort
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0171-967X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
303-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3111667-Adolescent,
pubmed-meshheading:3111667-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:3111667-Arthritis,
pubmed-meshheading:3111667-Body Height,
pubmed-meshheading:3111667-Bone Diseases, Metabolic,
pubmed-meshheading:3111667-Bone and Bones,
pubmed-meshheading:3111667-Calcifediol,
pubmed-meshheading:3111667-Calcium,
pubmed-meshheading:3111667-Child,
pubmed-meshheading:3111667-Child, Preschool,
pubmed-meshheading:3111667-Female,
pubmed-meshheading:3111667-Growth Disorders,
pubmed-meshheading:3111667-Humans,
pubmed-meshheading:3111667-Kidney Diseases,
pubmed-meshheading:3111667-Male,
pubmed-meshheading:3111667-Minerals,
pubmed-meshheading:3111667-Parathyroid Hormone,
pubmed-meshheading:3111667-Prednisone,
pubmed-meshheading:3111667-Pregnenediones
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pubmed:year |
1987
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pubmed:articleTitle |
Effects of long-term maintenance therapy with a new glucocorticoid, deflazacort, on mineral metabolism and statural growth.
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pubmed:publicationType |
Journal Article,
Comparative Study
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