Linked Life Data

3098147

Source:http://linkedlifedata.com/resource/pubmed/id/3098147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-1-15
pubmed:abstractText
The effects of increasing concentrations of tannin isolated from cotton bracts and endotoxin prepared from Enterobacter agglomerans on the electrophysiologic and ion transport properties of the canine tracheal epithelium mounted in Ussing chambers were examined. Results were compared with those obtained using cotton bracts extract (CBE). Tannin concentrations in the isolated tannin and in the cotton bracts were analyzed spectrophotometrically. When added to the mucosal bathing solution, tannin produced a significant decrease in transepithelial potential difference and short-circuit current (lsc) with a maximal response at 25 microliter. The decrease in lsc was accounted for entirely by a decrease in net chloride secretion. The effects were reversible and specific for the mucosal bathing solution. In contrast to CBE, tannin had no effect on mannitol flux, suggesting no effect on the paracellular pathway. Endotoxin at a concentration of 10 micrograms/ml had no effect on the electrophysiologic properties of the canine trachea. We conclude that tannin in CBE is responsible for the decrease in lsc observed with aqueous extracts of CBE but is not responsible for the changes in the paracellular pathway. We also conclude that endotoxin alone has no effect on the airway epithelium.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1158-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effects of endotoxin and tannin isolated from cotton bracts on the airway epithelium.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't