Switch to
Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0033689,
umls-concept:C0033692,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0243127,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0443331,
umls-concept:C0486616,
umls-concept:C0521457,
umls-concept:C1123023,
umls-concept:C1521828,
umls-concept:C1527148,
umls-concept:C2745955
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pubmed:issue |
3
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pubmed:dateCreated |
1986-3-3
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pubmed:abstractText |
Extraction of the skin of newborn rat yielded two populations of galactosaminoglycan-containing proteoglycan: a Mr = 111,000-200,000 dermatan sulfate proteoglycan (DS-PG) with a Mr congruent to 55,000 core glycoprotein and a Mr congruent to 10(6) chondroitin sulfate proteoglycan (CS-PGs) composed of two subpopulations with different size core-glycoproteins (Mr congruent to 480,000 and 520,000). Tryptic peptide mapping of chondroitinase-treated DS-PG and CS-PGs indicated that the peptide patterns observed with the two core molecules from CS-PGs were identical with each other but distinct from the peptide pattern of the DS-PG core molecule. It is likely therefore that the two forms of CS-PGs are derived from the same gene product by post-translational modification or partial degradation, but DS-PG is derived from a distinct gene product. Comparison of the concentration (hexuronate/DNA) of the proteoglycans in newborn and fetal rat skin showed an age-related change in proteoglycan composition; at 4 days before birth, the uronic acid proportions, DS-PG:CS-PGs, were about 14:1 and during the next 4 days, DS-PG increased 2.2-fold whereas CS-PGs decreased 4-fold. On a per DNA basis, the rate of [3H]serine incorporation into CS-PGs was 2.5 times the rate for DS-PG at 4 days before birth but decreased by 95% during the next 4 days. The rate for DS-PG also decreased but to a much lesser extent, so that by 2 days before birth, it began to exceed the rate for CS-PGs. The striking change in the concentration and labeling rate of CS-PGs can be interpreted either as a decrease of CS-PGs synthesis, or as an increase of CS-PGs breakdown, or both, a process which might be involved in the transition of extracellular matrix from a fetal type to a newborn or adult type.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chondroitin Sulfate Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9258
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
261
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1031-40
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3080414-Animals,
pubmed-meshheading:3080414-Centrifugation, Density Gradient,
pubmed-meshheading:3080414-Chondroitin Sulfate Proteoglycans,
pubmed-meshheading:3080414-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:3080414-Female,
pubmed-meshheading:3080414-Glucosamine,
pubmed-meshheading:3080414-Kinetics,
pubmed-meshheading:3080414-Molecular Weight,
pubmed-meshheading:3080414-Pregnancy,
pubmed-meshheading:3080414-Proteoglycans,
pubmed-meshheading:3080414-Rats,
pubmed-meshheading:3080414-Rats, Inbred Strains,
pubmed-meshheading:3080414-Serine,
pubmed-meshheading:3080414-Skin,
pubmed-meshheading:3080414-Trypsin
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pubmed:year |
1986
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pubmed:articleTitle |
Changes in proteoglycan composition during development of rat skin. The occurrence in fetal skin of a chondroitin sulfate proteoglycan with high turnover rate.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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