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| pubmed-article:3037999 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
| pubmed-article:3037999 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:3037999 | lifeskim:mentions | umls-concept:C0034428 | lld:lifeskim |
| pubmed-article:3037999 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:3037999 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3037999 | pubmed:dateCreated | 1987-7-24 | lld:pubmed |
| pubmed-article:3037999 | pubmed:abstractText | The mode of action of Ro 13-5478 and Ro 14-9578, monocyclic and tricyclic quinolone analogs, respectively, was examined for Escherichia coli and Staphylococcus aureus. The compounds showed antibacterial activity and effects on cell morphology, replicative DNA biosynthesis, and gyrase-catalyzed DNA supercoiling that were comparable to those shown by nalidixic acid and by oxolinic acid compounds. The results suggest that their site of action is DNA gyrase and that a bicyclic quinolone nucleus is not essential for activity. | lld:pubmed |
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| pubmed-article:3037999 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3037999 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3037999 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3037999 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3037999 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:3037999 | pubmed:author | pubmed-author:AngehrnPP | lld:pubmed |
| pubmed-article:3037999 | pubmed:author | pubmed-author:WickAA | lld:pubmed |
| pubmed-article:3037999 | pubmed:author | pubmed-author:Georgopapadak... | lld:pubmed |
| pubmed-article:3037999 | pubmed:author | pubmed-author:OlsonG LGL | lld:pubmed |
| pubmed-article:3037999 | pubmed:author | pubmed-author:DixB ABA | lld:pubmed |
| pubmed-article:3037999 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3037999 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:3037999 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3037999 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3037999 | pubmed:pagination | 614-6 | lld:pubmed |
| pubmed-article:3037999 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3037999 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3037999 | pubmed:articleTitle | Monocyclic and tricyclic analogs of quinolones: mechanism of action. | lld:pubmed |
| pubmed-article:3037999 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3037999 | pubmed:publicationType | Comparative Study | lld:pubmed |
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