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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1988-8-17
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pubmed:abstractText |
The S-100-positive T lymphocytes, and, particularly, the S-100 beta subunit, are restricted, as demonstrated by quantitative subset analysis and double-labeling (gold-peroxidase) immunoelectron microscopy of T-cell subpopulations, to an unique T8-positive cell subset which interestingly was 9.3-negative and CD11b-positive. Since both the T8-positive, 9.3-negative and the T8-positive, CD11b-positive subpopulations have been demonstrated to show suppressive activities, the S-100-positive T cells seem to be closely restricted to a small T-suppressor-cell compartment. Although functional studies on viable isolated S-100 beta-positive cells are impossible to achieve, due to the lack of this protein on the cell membrane, its presence in a discrete T-suppressor compartment might suggest a possible role for the S-100 beta-positive T cells in the regulation of the immune system.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-8749
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
398-404
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2968845-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2968845-Fluorescent Antibody Technique,
pubmed-meshheading:2968845-Humans,
pubmed-meshheading:2968845-Immunohistochemistry,
pubmed-meshheading:2968845-Microscopy, Electron,
pubmed-meshheading:2968845-Phenotype,
pubmed-meshheading:2968845-S100 Proteins,
pubmed-meshheading:2968845-T-Lymphocytes, Regulatory
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pubmed:year |
1988
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pubmed:articleTitle |
The S-100 beta protein in normal human peripheral blood is uniquely present within a discrete suppressor-T-cell compartment.
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pubmed:affiliation |
Department of Dermatology, University of Parma, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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