| pubmed-article:2957599 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2957599 | lifeskim:mentions | umls-concept:C0031298 | lld:lifeskim |
| pubmed-article:2957599 | lifeskim:mentions | umls-concept:C0034865 | lld:lifeskim |
| pubmed-article:2957599 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:2957599 | pubmed:issue | 6137 | lld:pubmed |
| pubmed-article:2957599 | pubmed:dateCreated | 1987-10-22 | lld:pubmed |
| pubmed-article:2957599 | pubmed:abstractText | General recombination shows a dependence on large regions of homology between the two participating segments of DNA. Many site-specific recombination systems also exhibit a dependence on homology, although in these systems the requirement is limited to a short region (less than 10 base pairs (bp]. We have used the in vitro phage lambda integration reaction to study the role of homology in this model site-specific recombination system. We find that certain non-homologous pairings which are strongly blocked for complete recombination, nevertheless make one pair of strand-exchanges to generate a joint molecule of the Holliday structure type. This result rules out recombination models in which the only homology-dependent step is synapsis (the juxtaposing of the two recombination sites). Our results also reveal a functional asymmetry in the recombination sites. We present models for bacteriophage lambda integrative recombination which accommodate these findings. | lld:pubmed |
| pubmed-article:2957599 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2957599 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2957599 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2957599 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2957599 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2957599 | pubmed:author | pubmed-author:NashH AHA | lld:pubmed |
| pubmed-article:2957599 | pubmed:author | pubmed-author:KittsP APA | lld:pubmed |
| pubmed-article:2957599 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2957599 | pubmed:volume | 329 | lld:pubmed |
| pubmed-article:2957599 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2957599 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2957599 | pubmed:pagination | 346-8 | lld:pubmed |
| pubmed-article:2957599 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2957599 | pubmed:articleTitle | Homology-dependent interactions in phage lambda site-specific recombination. | lld:pubmed |
| pubmed-article:2957599 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2957599 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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