| pubmed-article:2956329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C1706240 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C1335285 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2956329 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:2956329 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2956329 | pubmed:dateCreated | 1987-9-17 | lld:pubmed |
| pubmed-article:2956329 | pubmed:abstractText | We have examined the effect of exogenous IL 2 on cell surface antigen expression in LPS/dextran sulfate-activated murine B cells with the use of a panel of fluorescein-conjugated lectins. Elevated binding of the lectins PNA and SBA to activated B cells was found to be mediated by IL 2-containing supernatants from stimulated EL4 cells as well as by recombinant IL 2. These lectins have specificity for terminal beta-(1-3)-N-acetylgalactosaminyl residues; thus, the quantity or accessibility of these moieties is mediated by IL 2 in activated B lymphocytes. PNA binding in all strains tested, regardless of MHC or background genes, was found to be elevated fivefold to 15-fold by exogenous IL 2. To observe this effect, IL 2 must be added during the first 24 hr of culture. Based on anti-Thy-1 + complement depletion studies, T cells were not required, suggesting a direct effect of IL 2 on B cells. The glycoprotein responsible for this elevated binding of PNA has an Mr of approximately 220K and by immunodepletion was shown to belong to the T200 (Ly-5) family of cell surface antigens. These data demonstrate that exogenous IL 2 can mediate alterations in T200 expression on activated B cells that may be related to IL 2-driven modulation of B cell proliferation and/or differentiation. | lld:pubmed |
| pubmed-article:2956329 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2956329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2956329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2956329 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2956329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2956329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2956329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2956329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2956329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2956329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2956329 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2956329 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2956329 | pubmed:author | pubmed-author:LeoneJJ | lld:pubmed |
| pubmed-article:2956329 | pubmed:author | pubmed-author:CookR GRG | lld:pubmed |
| pubmed-article:2956329 | pubmed:author | pubmed-author:MehtaVV | lld:pubmed |
| pubmed-article:2956329 | pubmed:author | pubmed-author:LandolfiN FNF | lld:pubmed |
| pubmed-article:2956329 | pubmed:author | pubmed-author:HoylandDD | lld:pubmed |
| pubmed-article:2956329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2956329 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2956329 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:2956329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2956329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2956329 | pubmed:pagination | 991-7 | lld:pubmed |
| pubmed-article:2956329 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2956329 | pubmed:meshHeading | pubmed-meshheading:2956329-... | lld:pubmed |
| pubmed-article:2956329 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2956329 | pubmed:articleTitle | Interleukin 2 mediates an alteration in the T200 antigen expressed on activated B lymphocytes. | lld:pubmed |
| pubmed-article:2956329 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2956329 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2956329 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2956329 | lld:pubmed |
