Linked Life Data

2942205

Source:http://linkedlifedata.com/resource/pubmed/id/2942205

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-9-18
pubmed:abstractText
A specific deficiency in UDPG-linked trehalose-6-phosphate synthase in Saccharomyces has been associated with a single nuclear gene SST1 (M.S. Operti et al., Current Genetics, 5: 69-76, 1982). The sst1 phenotype was first observed in a pleiotropic fdp mutant which does not grow on mannose, sucrose, glucose or fructose, and in its partial spontaneous revertant (Q6R2) which acquired the capacity to grow on glucose but retained the mutant phenotype with respect to fructose. The sst1 mutants described in this paper are genetically derived from this partial revertant, a fact which suggested a link between sst1 and fdp mutations. All sst1 strains tested showed reduced growth on fructose in 24 h, which also characterizes the fdp mutation. Linkage studies revealed that the SST1 gene maps very close to the FDP gene. Furthermore, another mutant (cif) described as similar to fdp also lacked trehalose-6-phosphate synthase activity. Complementation tests between cif and fdp mutants indicated that the genes are allelic. These results suggest that SST1 and FDP are allelic and that the sst1 mutation might not be associated with the structural gene for trehalose-6-phosphate synthase but corresponds to one of the effects of the pleiotropic fdp mutation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
447-54
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Investigation of the relationship between sst1 and fdp mutations in yeast and their effect on trehalose synthesis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't