Linked Life Data

2935470

Source:http://linkedlifedata.com/resource/pubmed/id/2935470

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-3-3
pubmed:abstractText
Recent developments in technology have stimulated interest in the use of catheter-directed laser energy for removal of atherosclerotic plaques. Over the past three years, intensive research efforts by a number of investigators have defined the potential therapeutic benefit of laser angioplasty, as well as its limitations. Unlike balloon angioplasty, the laser has the capacity to remove totally atheromatous plaque or thrombus by photovaporization. Unique properties of the laser allow light energy to be concentrated for plaque removal. Arterial damage adjacent to the plaque is prevented by certain lasers, while others produce thermal injury to the arterial wall. Chemical pretreatment with vital dyes or drugs has been shown to enhance absorption of laser radiation by plaque and may enable selective destruction of the arterial plaque. Fiberoptic catheters have been designed to transmit laser energy to remote intravascular targets; however, precise guidance systems for catheter delivery have not been developed sufficiently for safe intracoronary application. Complete arterial healing by endothelial cell migration has been demonstrated after laser ablation of plaque in animal studies. Among the first four clinical trials of laser angioplasty, relief of atherosclerotic obstruction was successful using argon, neodymium-YAG, and carbon dioxide lasers. Despite the satisfactory initial appearance of laser-treated arteries, the long-term effects and risk of atherogenesis are undetermined. A potential risk of thrombosis has been identified after laser application, especially with the argon and NdYAG lasers. Further basic and clinical research are needed to establish the role of this promising new technology in the treatment of cardiovascular disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0340-9937
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-50
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The development of laser angioplasty.
pubmed:publicationType
Journal Article