Linked Life Data

2912802

Source:http://linkedlifedata.com/resource/pubmed/id/2912802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-3-3
pubmed:abstractText
During muscle maturation, isoform switching of contractile proteins to attain the adult phenotype involves both stage-specific and muscle-specific regulatory mechanisms. Chicken pectoralis major (PM) provides an interesting model to study the latter since a specific pattern of tropomyosin (TM) with repression of the beta TM isoform is displayed by the adult PM. The developmental pattern of alpha and beta fast skeletal muscle tropomyosins' (alpha f and beta TM) RNAs was investigated with 3' untranslated region specific probes. In PM, the beta TM messenger ceased to accumulate after hatching through a transcriptional control, as shown by run-on assays, so that, at Day 8 ex ovo, no beta TM mRNA was detected. In this same muscle, in parallel with the disappearance of the beta TM mRNA, there was a boost in the accumulation of the alpha f TM mRNA. In the leg muscles, following hatching, there was only a moderate increase in the level of the alpha f TM mRNA, together with a slight decrease in the accumulation of the beta TM mRNA. Taken together, these results show that chicken muscle maturation involves tissue-specific transcriptional control of tropomyosin genes and could suggest a possible coordinate regulation of the two genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
430-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Tissue-specific transcriptional control of alpha- and beta-tropomyosins in chicken muscle development.
pubmed:affiliation
Department of Molecular Biology, Pasteur Institute, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't