Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-9-29
pubmed:abstractText
CYP3, the gene which encodes the hepatic cytochrome P450pcn1, the isozyme responsible for the metabolic oxidation of the calcium channel-blocking drug nifedipine, has recently been mapped to human chromosome 7 using somatic cell hybrids. Using multilocus linkage analysis in CEPH families, we examined the linkage of a cDNA probe (hPCN1) for CYP3 to the oncogene MET, the pro-alpha 2(1) collagen gene COL1A2, and the T-cell receptor beta-chain gene TCRB, together with three arbitrary loci D7S8, D7S13, and D7S16, defined by the anonymous DNA probes pJ3.11, pB79a, and p7C22, respectively. From 70 CEPH parents screened with a StyI RFLP for hPCN1, four informative families were found each with both parental and maternal grandparents and 6-11 children per family. Tight linkage emerged between CYP3 and COL1A2, with a maximum combined lod score of 5.72 at theta = 0, suggesting the most likely subchromosomal localization of CYP3 is 7q21.3-q22.1.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-158499, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-2892400, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3123997, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3267210, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3304150, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3460094, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3464943, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3652049, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3689440, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3785219, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-3906407, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-499318, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-6329026, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-6417793, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-6472475, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-6508829, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-6587361, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-6644761, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-6714436, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-71400, http://linkedlifedata.com/resource/pubmed/commentcorrection/2901225-7381862
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
280-4
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1.
pubmed:affiliation
Department of Biochemistry, St. Mary's Hospital Medical School, London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't