| pubmed-article:2888059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2888059 | lifeskim:mentions | umls-concept:C0000254 | lld:lifeskim |
| pubmed-article:2888059 | lifeskim:mentions | umls-concept:C0031381 | lld:lifeskim |
| pubmed-article:2888059 | lifeskim:mentions | umls-concept:C0598695 | lld:lifeskim |
| pubmed-article:2888059 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2888059 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2888059 | pubmed:dateCreated | 1987-9-30 | lld:pubmed |
| pubmed-article:2888059 | pubmed:abstractText | D-(-)-2-Amino-5-phosphonovaleric acid (D(-)AP5), a selective, potent competitive antagonist of N-methyl-D-aspartate (NMDA)-type excitatory amino acid receptors was used to investigate the relationship between NMDA receptors and phencyclidine (PCP) binding. Incubation of rat brain membranes with D(-)AP5 decreased the apparent number of PCP/sigma-receptors in dose-dependent fashion without affecting their affinity for [2-thienyl-3H]cyclohexylpiperidine (TCP). These data, taken together with electrophysiological evidence that PCP non-competitively antagonizes NMDA receptor-mediated transmission, are consistent with the hypothesis that the PCP/sigma-receptor may be situated in or near a channel regulated by an NMDA receptor complex. | lld:pubmed |
| pubmed-article:2888059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2888059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2888059 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2888059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2888059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2888059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2888059 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2888059 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:2888059 | pubmed:author | pubmed-author:ZukinS RSR | lld:pubmed |
| pubmed-article:2888059 | pubmed:author | pubmed-author:JavittD CDC | lld:pubmed |
| pubmed-article:2888059 | pubmed:author | pubmed-author:JotkowitzAA | lld:pubmed |
| pubmed-article:2888059 | pubmed:author | pubmed-author:SircarRR | lld:pubmed |
| pubmed-article:2888059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2888059 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:2888059 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:2888059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2888059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2888059 | pubmed:pagination | 193-8 | lld:pubmed |
| pubmed-article:2888059 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:2888059 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2888059 | pubmed:articleTitle | Non-competitive regulation of phencyclidine/sigma-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid. | lld:pubmed |
| pubmed-article:2888059 | pubmed:publicationType | Journal Article | lld:pubmed |
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