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pubmed-article:2886336pubmed:abstractTextEnzymes of heme synthesis, porphyrins and heme content of regenerating rat livers were examined. During the first three days of regeneration the weights of livers of one-third and two-third hepatectomized rats increased 1.5-fold and 2.7-fold and the activity of porphobilinogen deaminase increased 2-fold and 4-fold and was inversely correlated with ferrochelatase activity. delta-Aminolevulinic acid synthase and delta-aminolevulinic acid dehydratase activities were reduced. Concomitantly an increase in the concentration of porphyrins and a decrease in that of heme were observed. The changes in the biosynthetic pathway of heme during rapid growth of the liver are discussed.lld:pubmed
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pubmed-article:2886336pubmed:articleTitleThe heme biosynthetic pathway in the regenerating rat liver. The relation between enzymes of heme synthesis and growth.lld:pubmed
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