Linked Life Data

2858180

Source:http://linkedlifedata.com/resource/pubmed/id/2858180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-3-28
pubmed:abstractText
The question 'Does the use of second-line therapy confer long-term benefit on outcome measures in rheumatoid arthritis?' remains unanswered. The major obstacle which prevents collection of the necessary data is the lack of a suitable control group. In this report experience with three 'second-line placebo groups' is described, and previous studies in the literature which incorporated a placebo group are reviewed. In the absence of concurrent corticosteroid therapy very few patients remain on placebo second-line medication after one year. Those that do, appear to have milder disease and are not representative of the group as a whole. Data on outcome measures need to be collected over two to five years, but the answer to the question which is posed does not depend upon larger and larger placebo groups which constitute increasing bias. To define the extent of benefit offered by the more powerful therapeutic agents a novel approach in regard to drug assessment will be required.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-11663225, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-13618213, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-18623717, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-4204032, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-4577392, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-6103452, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-6138117, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-6342625, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-6353231, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-6421253, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-6704285, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-7020612, http://linkedlifedata.com/resource/pubmed/commentcorrection/2858180-7221396
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0003-4967
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
134-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
A rheumatological dilemma: is it possible to modify the course of rheumatoid arthritis? Can we answer the question?
pubmed:publicationType
Journal Article, Clinical Trial, Review