Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3 Pt 2
|
| pubmed:dateCreated |
1988-10-12
|
| pubmed:abstractText |
Hemorrhage in rats produces reflex decreases in heart rate (HR) and renal sympathetic nerve activity (RSNA). Because serotonergic antagonists attenuate hemorrhage-induced vagal-mediated bradycardia, we determined whether blockade of serotonin synthesis by p-chlorophenylalanine (PCPA) or of serotonin receptors with methysergide would also abolish the renal sympathoinhibition. Mean arterial pressure (MAP), HR, and RSNA were recorded in chloralose-anesthetized rats pretreated with PCPA (300 mg.kg-1.day-1 X 3 days ip, n = 12) or vehicle (0.3 ml saline, n = 9). During hemorrhage, where MAP was maintained at 50 mmHg for 8 min, vehicle-treated rats decreased HR by 27 +/- 13 beats/min and RSNA by -55 +/- 7%. In PCPA-treated rats, HR and RSNA did not change. Cervical vagotomy abolished the bradycardia and sympathoinhibition during hemorrhage. After acute administration of methysergide (400 micrograms/kg iv, n = 8) hemorrhage produced increases of RSNA, whereas vehicle (0.5 ml saline, n = 7) preserved the renal sympathoinhibition to hemorrhage in conscious rats. Finally, volume expansion (0.88 ml blood/100 g body wt) produced comparable decreases in RSNA in sinoaortic-denervated rats pretreated with PCPA (n = 11) or vehicle (n = 10) (-58 +/- 9 vs. 47 +/- 7%, respectively). We conclude that serotonergic mechanisms are critically involved in vagal afferent inhibition of RSNA during severe hemorrhage in rats.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
255
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
H496-502
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2843055-Animals,
pubmed-meshheading:2843055-Blood Pressure,
pubmed-meshheading:2843055-Denervation,
pubmed-meshheading:2843055-Female,
pubmed-meshheading:2843055-Fenclonine,
pubmed-meshheading:2843055-Heart Rate,
pubmed-meshheading:2843055-Hemorrhage,
pubmed-meshheading:2843055-Kidney,
pubmed-meshheading:2843055-Methysergide,
pubmed-meshheading:2843055-Phenylephrine,
pubmed-meshheading:2843055-Pressoreceptors,
pubmed-meshheading:2843055-Rats,
pubmed-meshheading:2843055-Rats, Inbred Strains,
pubmed-meshheading:2843055-Reference Values,
pubmed-meshheading:2843055-Serotonin,
pubmed-meshheading:2843055-Sinus of Valsalva,
pubmed-meshheading:2843055-Sympathetic Nervous System,
pubmed-meshheading:2843055-Synaptic Transmission,
pubmed-meshheading:2843055-Vagotomy
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Serotonergic mechanisms mediate renal sympathoinhibition during severe hemorrhage in rats.
|
| pubmed:affiliation |
Veterans Administration Medical Center, Department of Medicine, Iowa City, Iowa.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|