rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1988-10-6
|
pubmed:abstractText |
Induction of differentiation in HL-60 and U-937 leukemic cell lines, resulted in 1.5-10-fold increase in 45Ca2+ uptake. The increased 45Ca2+ uptake in the differentiating cells was inhibited by verapamil, cromolyn and amiloride. Elevation in Ca2+ uptake in differentiating cells was also demonstrated using the fluorescent probe, fura-2 acetoxymethyl ester. The increased 45Ca2+ uptake was accompanied by a decrease in ouabain-insensitive and -sensitive 86Rb+ uptake. Furthermore, correlation between the changes in these activities was observed. Modulation of extracellular pH affected differentiation: higher pH increased the extent of differentiation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
29
|
pubmed:volume |
236
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
401-5
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2842190-Amiloride,
pubmed-meshheading:2842190-Biological Transport,
pubmed-meshheading:2842190-Calcium,
pubmed-meshheading:2842190-Carrier Proteins,
pubmed-meshheading:2842190-Cell Differentiation,
pubmed-meshheading:2842190-Cromolyn Sodium,
pubmed-meshheading:2842190-Humans,
pubmed-meshheading:2842190-Hydrogen-Ion Concentration,
pubmed-meshheading:2842190-Leukemia, Monocytic, Acute,
pubmed-meshheading:2842190-Leukemia, Myeloid, Acute,
pubmed-meshheading:2842190-Potassium,
pubmed-meshheading:2842190-Rubidium,
pubmed-meshheading:2842190-Sodium-Hydrogen Antiporter,
pubmed-meshheading:2842190-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:2842190-Tumor Cells, Cultured,
pubmed-meshheading:2842190-Verapamil
|
pubmed:year |
1988
|
pubmed:articleTitle |
Differentiation-associated changes of cation-transport activities in myeloid leukemic cell lines.
|
pubmed:affiliation |
Hematology Division, Beilinson Medical Center, Petach-Tikva, Israel.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|