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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1988-8-5
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pubmed:abstractText |
We report a randomized multicentre study of split-course radiotherapy (RT), with or without combination chemotherapy (CT), in 238 patients with inoperable non-small cell lung cancer (NSCLC), previously untreated, confined to one hemithorax and the mediastinal nodes. In both treatment groups RT consisted of 55 Gy in 20 F given over 7 weeks with a 3-week rest interval. CT consisted of the 3-drug regimen CAP: C = cyclophosphamide 400 mg/m2, A = adriamycin 40 mg/m2, P = cisplatin 40 mg/m2; 2 cycles of CAP given before RT, one during the rest interval and six after RT. Seventy per cent in the RT arm and 67% in the RT-CT arm had epidermoid carcinoma. No significant difference was apparent between the RT and the RT-CT arms with respect to objective response rates (CR + PR) (44 and 49%, respectively), median duration of response (278 and 320 days), local failure (31 and 20%), distant progression (23 and 20%) or median survival (311 and 322 days). The survival figures showed an almost significant (P = 0.05) therapeutic advantage of the combined regimen with stage IIIM0 disease. Progressive disease was the cause of death in 92% and 88%. We conclude that chemotherapy did not contribute significantly to either local control or survival as compared to radiotherapy alone.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0277-5379
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
24
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
477-82
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:2838288-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2838288-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:2838288-Cisplatin,
pubmed-meshheading:2838288-Combined Modality Therapy,
pubmed-meshheading:2838288-Cyclophosphamide,
pubmed-meshheading:2838288-Doxorubicin,
pubmed-meshheading:2838288-Humans,
pubmed-meshheading:2838288-Lung Neoplasms,
pubmed-meshheading:2838288-Middle Aged,
pubmed-meshheading:2838288-Prognosis,
pubmed-meshheading:2838288-Radiotherapy Dosage,
pubmed-meshheading:2838288-Random Allocation
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pubmed:year |
1988
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pubmed:articleTitle |
Inoperable non-small cell lung cancer: radiation with or without chemotherapy.
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pubmed:affiliation |
University Central Hospital of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|