Linked Life Data

2838164

Source:http://linkedlifedata.com/resource/pubmed/id/2838164

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-8-4
pubmed:abstractText
The inhibitory effects of triterpene glycosides and monoterpene glycosides on 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin B in the Epstein-Barr virus (EBV) activation in Raji cells were studied. Concomitant treatment of Raji cells with TPA or Teleocidin B and these glycosides showed the inhibition of EBV activation. We herein report in vitro structure-activity studies using a biological test system on a variety of triterpene glycosides having 1 sugar chain (monodesmoside), 2 sugar chain (bisdesmoside) and an acyl side-chain. Among these glycosides, triterpene 3-O-glycosides and acylated saponin exhibited an effective inhibition of EBV activation; therefore, the sugar chain at C-3 of the triterpene and/or the acyl side-chain were determined to be essential to the inhibitory activities in this test system. The data suggested that these triterpenoid glycosides which were originally used as herbal drugs and folk remedies in many areas of the world, were in fact inhibitory compounds, thus explaining the EBV activation in the in vitro test system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-17
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate and teleocidin B induced Epstein-Barr virus by saponin and its related compounds.
pubmed:affiliation
Department of Microbiology, Faculty of Medicine, Kyoto University, Japan.
pubmed:publicationType
Journal Article, Comparative Study