Linked Life Data

2807101

Source:http://linkedlifedata.com/resource/pubmed/id/2807101

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1989-12-15
pubmed:abstractText
A long-term feeding study was carried out in rats with sodium nitrite. The test substance was administered as part of a reduced-protein diet to groups of 50, 6-wk-old, male F344 rats at dose levels of 0.2 or 0.5% (w/w) sodium nitrite for up to 115 wk. A control group of 20 males received the reduced-protein diet alone. Throughout the study, there was a dose-related decrease in the rates of body-weight gains and a corresponding decrease in body weights among animals fed sodium nitrite in the diet. Food intakes of rats in the low-dose group were slightly raised over most of the study. In the high-dose group, food intakes were reduced during the first month, but thereafter were similar to those of the control group. This reduction in food intake together with the lower body weights in the nitrite-treated animals, may indicate a reduction in food utilization. In the first week of treatment the following haematological parameters were reduced: red blood cell count, haematocrit and haemoglobin concentration. The red blood cell count continued to fall for 8 wk, then slowly returned to normal by wk 52. A dose-related reduction was noted in both the incidence and time of onset of lymphomas, leukaemias and testicular interstitial cell tumours. Leukaemias were only found in animals with lymphoma, indicating an association between the two lesions. Under the conditions described in this study, sodium nitrite was found not to be carcinogenic when fed to rats in the diet for up to 115 wk, but rather that the incidence of tumours was reduced in a dose-related manner, which correlated with a similar trend in body weights.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0278-6915
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
565-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Chronic toxicity of sodium nitrite in the male F344 rat.
pubmed:affiliation
British Industrial Biological Research Association, Carshalton, Surrey, England.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't