Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-8-2
pubmed:abstractText
Bradykinin is a nonapeptide, which may act as a mediator in asthma since it is generated upon nasal immunological challenge in vivo and it has been shown to induce some asthma-like symptoms. In vitro studies suggest that refractoriness following bradykinin challenge may be due to release of contractile tachykinins. In this study it was shown that repeated bronchial challenge with bradykinin in atopic asthmatic subjects induced loss of response to the nonapeptide. Once achieved, reduced bradykinin responsiveness was not accompanied by loss of airways response to histamine. Moreover, repeated challenge with histamine failed to produce a significant loss of airways response to this agonist. In conclusion, either the depletion of contractile tachykinins or the down-regulation at the level of specific kinin receptors might account for the refractoriness following repeated inhalation of bradykinin in asthmatic subjects.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0392-6516
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Tachyphylaxis induced by repeated inhalation of bradykinin in asthmatic patients].
pubmed:publicationType
Journal Article, English Abstract