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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-6-29
|
| pubmed:abstractText |
The brain histidine level in mice dose-dependently increased 1 and 2 hr after an i.p. injection of 0.5-1.5 g/kg of L-histidine. The treatment with 1.0 and 1.5 g/kg but not 0.5 g/kg of L-histidine significantly decreased the brain levels of tyrosine, phenylalanine and some other amino acids 1 hr later. A complete recovery or a rebound rise of amino acid levels was observed 2 hr after treatment. These results indicate that there is a change in the transport of amino acids into the brain after treatment with large doses of L-histidine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0021-5198
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
143-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2724677-Amino Acids,
pubmed-meshheading:2724677-Animals,
pubmed-meshheading:2724677-Brain Chemistry,
pubmed-meshheading:2724677-Dose-Response Relationship, Drug,
pubmed-meshheading:2724677-Histidine,
pubmed-meshheading:2724677-Male,
pubmed-meshheading:2724677-Mice,
pubmed-meshheading:2724677-Time Factors
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Effect of acute treatment of mice with L-histidine on the brain levels of amino acids.
|
| pubmed:affiliation |
Department of Pharmacology, Okayama University Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|