Linked Life Data

2719758

Source:http://linkedlifedata.com/resource/pubmed/id/2719758

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-6-22
pubmed:abstractText
Effects of dietary proteins on intestinal lipoproteins were studied in 8 Yorkshire swine fed a high fat, high cholesterol diet with either casein or soy protein. After 5 weeks of feeding, the casein group exhibited moderately elevated levels of serum cholesterol (334 +/- 46 mg/dl). The soy protein group showed significantly less hypercholesterolemia as compared to the casein group (122 +/- 8 mg/dl). Swine were subjected to cannulation of mesenteric lymph duct under halothane anesthesia. A single dose of 250 microCi [14C]cholesterol and 10 mCi [3H]leucine was infused into the upper jejunum 2 h after one-fifth of daily food was given. The 3-h lymphatic transport of cholesterol in casein-fed swine was significantly higher than in those fed soy protein. Triglyceride transport values were similar in the 2 groups. The [3H]leucine incorporation study revealed that transport of apo B-48 bore a significant positive relationship to transport of cholesterol in both chylomicron and VLDL fractions of mesenteric lymph. A greater apo B-48 secretion with higher specific activity was probably responsible for the greater transport of cholesterol in chylomicrons in casein-fed than in soy protein-fed swine. Similarly, the transport of lymph VLDL cholesterol in swine fed casein or soy protein paralleled the amount of accompanying apo B-48. Dietary proteins probably influence the intestinal synthesis of apo B-48 which in turn affects cholesterol transport into the lymphatics.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:2719758-Amino Acids, pubmed-meshheading:2719758-Animals, pubmed-meshheading:2719758-Apolipoprotein B-48, pubmed-meshheading:2719758-Apolipoproteins B, pubmed-meshheading:2719758-Biological Transport, pubmed-meshheading:2719758-Caseins, pubmed-meshheading:2719758-Cholesterol, Dietary, pubmed-meshheading:2719758-Cholesterol, VLDL, pubmed-meshheading:2719758-Dietary Fats, pubmed-meshheading:2719758-Dietary Proteins, pubmed-meshheading:2719758-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:2719758-Hypercholesterolemia, pubmed-meshheading:2719758-Intestinal Absorption, pubmed-meshheading:2719758-Lymphatic System, pubmed-meshheading:2719758-Male, pubmed-meshheading:2719758-Soybean Proteins, pubmed-meshheading:2719758-Soybeans, pubmed-meshheading:2719758-Swine, pubmed-meshheading:2719758-Vegetable Proteins
pubmed:year
1989
pubmed:articleTitle
Intestinal apolipoprotein B-48 synthesis and lymphatic cholesterol transport are lower in swine fed high fat, high cholesterol diet with soy protein than with casein.
pubmed:affiliation
Department of Pathology, Neil Hellman Medical Research Building, Albany Medical College, NY 12208.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.