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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0023745,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0085117,
umls-concept:C0162326,
umls-concept:C0205485,
umls-concept:C0926407,
umls-concept:C1511695,
umls-concept:C1521840,
umls-concept:C1522240,
umls-concept:C1705535
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pubmed:issue |
2
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pubmed:dateCreated |
1989-5-26
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pubmed:abstractText |
The first complete map of a mammalian immunoglobulin gene locus is presented. Mouse lambda genes were mapped by pulsed-field gel electrophoresis. The gene order is V2-Vx-C2-C4-V1-C3-C1. The distance between V2 or Vx and the C2-C4 cluster is 74 or 55 kilobases (kb), respectively, whereas that between V1 and C3-C1 is only 19 kb; V2 and C3-C1 are at least 190 kb apart. Thus, the distances between the lambda subloci are inversely proportional to their frequencies of rearrangement. The related gene lambda 5 is not within the 500 kb of the lambda locus mapped here.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-103630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-113458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-2831502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-2961997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3005116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3011279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3024017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3034625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3035056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-303524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3107979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3110349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3117530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3122215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3139761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3139764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3273395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3484682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3917859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3933530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-3975629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-418414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6092962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6156004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6166864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6267606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6373014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6379602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6402777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6419128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6443559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6791160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6799835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710121-6812053
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
711-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2710121-Animals,
pubmed-meshheading:2710121-Chromosome Mapping,
pubmed-meshheading:2710121-Cloning, Molecular,
pubmed-meshheading:2710121-DNA Probes,
pubmed-meshheading:2710121-Electrophoresis, Agar Gel,
pubmed-meshheading:2710121-Gene Rearrangement, B-Lymphocyte, Light Chain,
pubmed-meshheading:2710121-Genetic Linkage,
pubmed-meshheading:2710121-Mice,
pubmed-meshheading:2710121-Restriction Mapping
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pubmed:year |
1989
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pubmed:articleTitle |
Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.
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pubmed:affiliation |
Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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