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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1990-3-9
|
| pubmed:abstractText |
Dihydroartemisinine (DHA) is a derivative of qinghaosu(artemisine), which is an antimalarial drug. DHA was given to mice inoculated with Plasmodium berhgei ANKA strain by intramuscular injection. Within proper dose range, the dose-effect and time-effect curves of DHA against the malaria can be described by y = 4.9960 + 2.9536 x and y = 7.2654 - 0.3414 t, respectively, where y is the estimated value of parasitemia suppressing rate in probit; x is log dose; t is the period since drug administration im. Accordingly, the ED50 = 1.00 +/- 0.13 mg/kg and the time of half-effect was 6.6 h, when the dose was 5.0 mg/kg im. The elimination rate constant of the effective dose in vivo was 0.2662h-1 with a half-life of 2.6 h.
|
| pubmed:language |
chi
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0513-4870
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
487-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2694757-Animals,
pubmed-meshheading:2694757-Antimalarials,
pubmed-meshheading:2694757-Artemisinins,
pubmed-meshheading:2694757-Dose-Response Relationship, Drug,
pubmed-meshheading:2694757-Malaria,
pubmed-meshheading:2694757-Male,
pubmed-meshheading:2694757-Mice,
pubmed-meshheading:2694757-Plasmodium berghei,
pubmed-meshheading:2694757-Sesquiterpenes,
pubmed-meshheading:2694757-Time Factors
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
[Pharmacodynamics of dihydroartemisinine against Plasmodium berghei in mice].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|