Linked Life Data

267715

Source:http://linkedlifedata.com/resource/pubmed/id/267715

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1977-9-29
pubmed:abstractText
Mean survival times were increased an average of 23, 53 and 61%, when 10, 15, and 20 mg/kg, respectively, of the organoplatinum congener, malonato(1,2-diaminocyclohexane) platinum(II)(NSC-224964), was given as the only treatment modality to BDF1 mice bearing 1-day-old L1210 leukemia. When a single dose of 10 mg/kg was combined with either 300 or 100 R on day 1 only, the anticipated response (ILS = 30 and 38%, respectively) based on the additive effects of the single modalities was surpassed by 26 and 21%, respectively (i.e. extent of therapeutic synergism). When divided doses of radiation (200 R/day x 3 days) were combined with 15 or 20 mg/kg of NSC-224964, survival times were enhanced an average of 15% (extent of synergism) greater than would be expected if these modalities were acting through an additive process(es).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0025-7850
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Antileukemic properties of combinations of radiation and malonato(1,2-diaminocyclohexane) platinum(ii) (NSC-224964).
pubmed:publicationType
Journal Article