Linked Life Data

2668841

Source:http://linkedlifedata.com/resource/pubmed/id/2668841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1989-9-20
pubmed:abstractText
The authors treated 14 insulin-allergic diabetic patients in 1985-87. Previous short-term therapy with conventional insulins could be verified in 12 cases. The "presensitizing" effect of this transient treatment seems highly probable. Five of the 14 patients were allergic to all animal insulins incl. monospecies porcine monocomponent (MC) preparations. Surprisingly, all these patients proved to be allergic to biosynthetic human insulin (Huminsulin Normal and Huminsulin Basal) preparations too, but two of them could be treated with semisynthetic human insulins (Actrapid HM and Monotard HM). Another patient was able to receive Monotard HM exclusively. The remaining two patients proved to be allergic to all human insulins used. One of them was desensitized but the insulin therapy had to be supplemented with steroid drugs for two years. The fifth patient continued the oral treatment but her metabolism is poorly controlled. These results show that some diabetics with allergy to animal insulins are allergic to human insulins as well. As a prevention, transient therapy with conventional preparations should be avoided. If, however, there is an absolute indication for it (e.g. gestational diabetes or surgical intervention), it should be carried out with human insulin, or, if that is not available, with monospecies porcine MC insulin.
pubmed:language
hun
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0030-6002
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1159-62
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[The use of human insulin in cases of insulin allergy].
pubmed:publicationType
Journal Article, English Abstract, Review