Linked Life Data

2661550

Source:http://linkedlifedata.com/resource/pubmed/id/2661550

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-8-10
pubmed:abstractText
Therapeutic drug monitoring (TDM) of tricyclic antidepressants (TCAs) is a cost-effective tool that can improve both the safety and efficacy of TCA pharmacotherapy. By understanding the principles behind TDM, the physician can rationally interpret plasma TCA levels and avoid spurious results. The following features of TDM of TCAs are reviewed: (1) the relationships between TCA concentration in plasma and the multiple pharmacologic actions and clinical effects of TCAs, (2) the use of TDM to improve antidepressant efficacy while avoiding both cardiac and brain toxicity, (3) the protocol to follow when using TDM of TCAs and the rationale behind it, and (4) common laboratory errors that can be readily avoided but that could otherwise lead to spurious results.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0160-6689
pubmed:author
pubmed:issnType
Print
pubmed:volume
50 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34-42; discussion 43-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Tricyclic antidepressants: the whys and hows of therapeutic drug monitoring.
pubmed:affiliation
Department of Psychiatry, University of Kansas School of Medicine, Wichita.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't