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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
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|
pubmed:dateCreated |
1990-3-6
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|
pubmed:abstractText |
Intraplantar administration of serotonin 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 (1-100 micrograms; 50 microliters) produced dose-related analgesia against formalin-induced acute- and Freunds adjuvant-induced chronic-inflammatory pain in rats. 5-HT3 receptor antagonists had greater effect in the chronic pain test than in the acute paradigm. In both tests, ICS 205-930 was more potent than MDL 72222. These data further support the involvement of peripheral 5-HT3 sites in inflammatory pain, and suggest the utility of selective 5-HT3 receptor antagonists as peripheral analgesics.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Oct
|
|
pubmed:issn |
0014-2999
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
24
|
|
pubmed:volume |
170
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
83-6
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2612565-Acute Disease,
pubmed-meshheading:2612565-Analgesics,
pubmed-meshheading:2612565-Animals,
pubmed-meshheading:2612565-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:2612565-Chronic Disease,
pubmed-meshheading:2612565-Indoles,
pubmed-meshheading:2612565-Male,
pubmed-meshheading:2612565-Nociceptors,
pubmed-meshheading:2612565-Pain Measurement,
pubmed-meshheading:2612565-Rats,
pubmed-meshheading:2612565-Serotonin Antagonists,
pubmed-meshheading:2612565-Tropanes
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|
pubmed:year |
1989
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|
pubmed:articleTitle |
Peripherally administered serotonin 5-HT3 receptor antagonists reduce inflammatory pain in rats.
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|
pubmed:affiliation |
Neuropharmacology Laboratory, College of Pharmacy and Health Sciences, Drake University, Des Moines, IA 50311.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
