| pubmed-article:2564639 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2564639 | lifeskim:mentions | umls-concept:C1517884 | lld:lifeskim |
| pubmed-article:2564639 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2564639 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:2564639 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:2564639 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:2564639 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:2564639 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:2564639 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:2564639 | pubmed:issue | 6214 | lld:pubmed |
| pubmed-article:2564639 | pubmed:dateCreated | 1989-4-28 | lld:pubmed |
| pubmed-article:2564639 | pubmed:abstractText | The spatial organization of the Drosophila embryo depends on the activity of three axial pattern-forming systems. In addition to the anterior-posterior and dorsal-ventral systems that organize the segmented body plan, a proximal-distal pattern-forming system is required to provide positional information for the developing limbs. The development of both the larval and adult limbs depends directly on the activity of the Distal-less gene. Genetic analysis has shown that Distal-less functions as a developmental switch that is required to promote the development of limb structures above the evolutionary ground-state of body wall. Here we provide genetic evidence that indicates a graded requirement for Distal-less activity during limb development. Reduction of this activity has a global effect on pattern formation in the limb. The molecular structure of the Distal-less locus indicates that the gene encodes a homoeodomain-containing protein which is therefore likely to specify limb development through differential regulation of subordinate genes. | lld:pubmed |
| pubmed-article:2564639 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2564639 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2564639 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2564639 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2564639 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2564639 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2564639 | pubmed:author | pubmed-author:CohenS MSM | lld:pubmed |
| pubmed-article:2564639 | pubmed:author | pubmed-author:JäckleHH | lld:pubmed |
| pubmed-article:2564639 | pubmed:author | pubmed-author:JürgensGG | lld:pubmed |
| pubmed-article:2564639 | pubmed:author | pubmed-author:BrönnerGG | lld:pubmed |
| pubmed-article:2564639 | pubmed:author | pubmed-author:KüttnerFF | lld:pubmed |
| pubmed-article:2564639 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2564639 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:2564639 | pubmed:volume | 338 | lld:pubmed |
| pubmed-article:2564639 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2564639 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2564639 | pubmed:pagination | 432-4 | lld:pubmed |
| pubmed-article:2564639 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2564639 | pubmed:meshHeading | pubmed-meshheading:2564639-... | lld:pubmed |
| pubmed-article:2564639 | pubmed:meshHeading | pubmed-meshheading:2564639-... | lld:pubmed |
| pubmed-article:2564639 | pubmed:meshHeading | pubmed-meshheading:2564639-... | lld:pubmed |
| pubmed-article:2564639 | pubmed:meshHeading | pubmed-meshheading:2564639-... | lld:pubmed |
| pubmed-article:2564639 | pubmed:meshHeading | pubmed-meshheading:2564639-... | lld:pubmed |
| pubmed-article:2564639 | pubmed:meshHeading | pubmed-meshheading:2564639-... | lld:pubmed |
| pubmed-article:2564639 | pubmed:meshHeading | pubmed-meshheading:2564639-... | lld:pubmed |
| pubmed-article:2564639 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2564639 | pubmed:articleTitle | Distal-less encodes a homoeodomain protein required for limb development in Drosophila. | lld:pubmed |
| pubmed-article:2564639 | pubmed:affiliation | Max-Planck-Institut für Entwicklungsbiologie, Tübingen, FRG. | lld:pubmed |
| pubmed-article:2564639 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2564639 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:37973 | entrezgene:pubmed | pubmed-article:2564639 | lld:entrezgene |
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