| pubmed-article:2560511 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2560511 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:2560511 | lifeskim:mentions | umls-concept:C0598401 | lld:lifeskim |
| pubmed-article:2560511 | pubmed:issue | 1-6 | lld:pubmed |
| pubmed-article:2560511 | pubmed:dateCreated | 1990-3-30 | lld:pubmed |
| pubmed-article:2560511 | pubmed:abstractText | Estrogen sulfates are quantitatively the most important form of circulating estrogens during the menstrual cycle and in the post-menopausal period. Huge quantities of estrone sulfate and estradiol sulfate are found in the breast tissues of patients with mammary carcinoma. It has been demonstrated that different estrogen-3-sulfates (estrone-3-sulfate, estradiol-3-sulfate, estriol-3-sulfate) can provoke important biological responses in different mammary cancer cell lines: there is a significant increase in progesterone receptor. On the other hand, no significant effect was observed with estrogen-17-sulfates. The reason for the biological response of estrogen-3-sulfates is that these sulfates are hydrolyzed, and no sulfatase activity for C17-sulfates is present in these cell lines. [3H]Estrone sulfate is converted in a very high percentage to estradiol (E2) in different hormone-dependent mammary cancer cell lines (MCF-7, R-27, T-47D), but very little or no conversion was found in the hormone-independent mammary cancer cell lines (MDA-MB-231, MDA-MB-436). Different anti-estrogens (tamoxifen and derivatives) and another potent anti-estrogen: ICI 164,384, decrease the concentration of estradiol very significantly after incubation of estrone sulfate with the different hormone-dependent mammary cancer cell lines. No significant effect was observed for the uptake and conversion of estrone sulfate in the hormone-independent mammary cancer cell lines. Progesterone provokes an important decrease in the uptake and in estradiol levels after incubation of [3H]estrone sulfate with the MCF-7 cells. It is concluded that in breast cancer: (1) Estrogen sulfates can play an important role in the biological response of estrogens; (2) Anti-estrogens and progesterone significantly decrease the uptake and estradiol levels in hormone-dependent mammary cancer cell lines; (3) The control of the sulfatase and 17 beta-hydroxysteroid dehydrogenase activities, which are key steps in the formation of estradiol in the breast, can open new possibilities in the treatment of hormone-dependent mammary cancer. | lld:pubmed |
| pubmed-article:2560511 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2560511 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2560511 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2560511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2560511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2560511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2560511 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2560511 | pubmed:issn | 0022-4731 | lld:pubmed |
| pubmed-article:2560511 | pubmed:author | pubmed-author:PasqualiniJ... | lld:pubmed |
| pubmed-article:2560511 | pubmed:author | pubmed-author:NguyenB LBL | lld:pubmed |
| pubmed-article:2560511 | pubmed:author | pubmed-author:GellyCC | lld:pubmed |
| pubmed-article:2560511 | pubmed:author | pubmed-author:VelleGG | lld:pubmed |
| pubmed-article:2560511 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2560511 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:2560511 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2560511 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2560511 | pubmed:pagination | 155-63 | lld:pubmed |
| pubmed-article:2560511 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2560511 | pubmed:meshHeading | pubmed-meshheading:2560511-... | lld:pubmed |
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| pubmed-article:2560511 | pubmed:meshHeading | pubmed-meshheading:2560511-... | lld:pubmed |
| pubmed-article:2560511 | pubmed:meshHeading | pubmed-meshheading:2560511-... | lld:pubmed |
| pubmed-article:2560511 | pubmed:meshHeading | pubmed-meshheading:2560511-... | lld:pubmed |
| pubmed-article:2560511 | pubmed:meshHeading | pubmed-meshheading:2560511-... | lld:pubmed |
| pubmed-article:2560511 | pubmed:meshHeading | pubmed-meshheading:2560511-... | lld:pubmed |
| pubmed-article:2560511 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2560511 | pubmed:articleTitle | Importance of estrogen sulfates in breast cancer. | lld:pubmed |
| pubmed-article:2560511 | pubmed:affiliation | C.N.R.S. Steroid Hormone Research Unit, Foundation for Hormone Research, Paris, France. | lld:pubmed |
| pubmed-article:2560511 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2560511 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:2560511 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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