| pubmed-article:2528411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2528411 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2528411 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:2528411 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:2528411 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2528411 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2528411 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2528411 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2528411 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2528411 | pubmed:dateCreated | 1989-10-18 | lld:pubmed |
| pubmed-article:2528411 | pubmed:abstractText | We have constructed a hybrid immunoglobulin (VDJH)-T cell receptor (C alpha) gene using the VDJH exon from a digoxin-specific antibody. This gene was used to make a line of transgenic mice. The hybrid VDJH-C alpha protein is expressed on a subset of T cells in these mice, and we have shown that it forms part of a functional TCR complex by the criteria of coprecipitation and comodulation of CD3 and TCR beta chain components and T cell activation with anti-idiotypic antibodies or digoxin. Furthermore, in cells expressing the hybrid protein, there is allelic exclusion of endogenous TCR alpha genes. We discuss the implications for the comparative structure of T cell receptors and immunoglobulins. | lld:pubmed |
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| pubmed-article:2528411 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2528411 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2528411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2528411 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2528411 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2528411 | pubmed:author | pubmed-author:MargoliesM... | lld:pubmed |
| pubmed-article:2528411 | pubmed:author | pubmed-author:KuboR TRT | lld:pubmed |
| pubmed-article:2528411 | pubmed:author | pubmed-author:Mudgett-Hunte... | lld:pubmed |
| pubmed-article:2528411 | pubmed:author | pubmed-author:HedrickS MSM | lld:pubmed |
| pubmed-article:2528411 | pubmed:author | pubmed-author:KayeJJ | lld:pubmed |
| pubmed-article:2528411 | pubmed:author | pubmed-author:BeckerM LML | lld:pubmed |
| pubmed-article:2528411 | pubmed:author | pubmed-author:NearRR | lld:pubmed |
| pubmed-article:2528411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2528411 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:2528411 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:2528411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2528411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2528411 | pubmed:pagination | 911-21 | lld:pubmed |
| pubmed-article:2528411 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2528411 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2528411 | pubmed:articleTitle | Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. | lld:pubmed |
| pubmed-article:2528411 | pubmed:affiliation | Department of Biology and Cancer Center, University of California at San Diego, La Jolla 92093. | lld:pubmed |
| pubmed-article:2528411 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2528411 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2528411 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2528411 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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