|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1990-1-5
|
|
pubmed:abstractText |
The human proto-oncogene product, c-Jun, is a member of the AP-1 family of transcription factors, which mediate the regulation of gene expression in response to extracellular signaling. Comparison of c-Jun and v-Jun by in vitro transcription assays revealed that v-Jun has significantly greater transcriptional activity than c-Jun. Analysis of Jun mutants expressed in bacteria indicates that this difference in transcriptional activity is due to the presence of a regulatory domain located at the N-terminal region of c-Jun. Other Jun mutants identify an activation domain rich in acidic and proline residues toward the C-terminal end of the molecule, in a region near the DNA binding domain. These findings suggest that during retroviral transduction, a constitutively active Jun protein has been generated by deleting a negatively acting domain. This putative repressor domain may also play a role in the signal-dependent induction of c-Jun activity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
709-17
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:2510934-Amino Acid Sequence,
pubmed-meshheading:2510934-Cell Transformation, Viral,
pubmed-meshheading:2510934-Cloning, Molecular,
pubmed-meshheading:2510934-DNA-Binding Proteins,
pubmed-meshheading:2510934-Escherichia coli,
pubmed-meshheading:2510934-Gene Expression Regulation,
pubmed-meshheading:2510934-HeLa Cells,
pubmed-meshheading:2510934-Humans,
pubmed-meshheading:2510934-Molecular Sequence Data,
pubmed-meshheading:2510934-Mutation,
pubmed-meshheading:2510934-Oncogene Protein p65(gag-jun),
pubmed-meshheading:2510934-Plasmids,
pubmed-meshheading:2510934-Protein Processing, Post-Translational,
pubmed-meshheading:2510934-Protein-Tyrosine Kinases,
pubmed-meshheading:2510934-Proto-Oncogene Proteins,
pubmed-meshheading:2510934-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:2510934-Proto-Oncogenes,
pubmed-meshheading:2510934-Retroviridae Proteins, Oncogenic,
pubmed-meshheading:2510934-Transcription, Genetic,
pubmed-meshheading:2510934-Transcription Factors
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Biochemical analysis of transcriptional activation by Jun: differential activity of c- and v-Jun.
|
|
pubmed:affiliation |
Department of Biochemistry, University of California, Berkeley 94720.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
