| pubmed-article:2497094 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2497094 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:2497094 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2497094 | lifeskim:mentions | umls-concept:C1522449 | lld:lifeskim |
| pubmed-article:2497094 | lifeskim:mentions | umls-concept:C0522537 | lld:lifeskim |
| pubmed-article:2497094 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:2497094 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:2497094 | lifeskim:mentions | umls-concept:C0054692 | lld:lifeskim |
| pubmed-article:2497094 | lifeskim:mentions | umls-concept:C0598452 | lld:lifeskim |
| pubmed-article:2497094 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2497094 | pubmed:dateCreated | 1989-6-19 | lld:pubmed |
| pubmed-article:2497094 | pubmed:abstractText | The effects of two new perfluorochemical emulsions based on F-66E and PFOB which carry, in combination with carbogen, more oxygen than Fluosol-DA 20% were investigated on a human tumor xenograft (HRT18). Tumor bearing mice were pretreated with 15 ml/kg of F-66E emulsion (50 w/v%) or PFOB (100 w/v%) emulsion in the presence of carbogen for 1 hr prior to and during irradiation. F-66E emulsion was non toxic in vitro. In vivo, the dose modifying factor was 1.8 for mice pretreated with carbogen and F-66E emulsion whereas it was 1.6 for carbogen-breathing mice. Results with PFOB emulsion were similar to those obtained with F-66E emulsion. The effect of F-66E emulsion was studied using a fractionated radiation treatment: 12 Gy were delivered in 6 fractions of 2 Gy with an interval of 8 hrs between fractions. A single dose of F-66E emulsion was injected before the first irradiation. Surviving fractions were 0.35 for air-breathing mice, 0.091 for carbogen-breathing mice and 0.099 for carbogen-breathing mice pretreated with F-66E emulsion. These results showed that carbogen alone or carbogen plus F-66E or PFOB emulsion were very efficient even with low doses of radiation. | lld:pubmed |
| pubmed-article:2497094 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2497094 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2497094 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2497094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2497094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2497094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2497094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2497094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2497094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2497094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2497094 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2497094 | pubmed:month | May | lld:pubmed |
| pubmed-article:2497094 | pubmed:issn | 0360-3016 | lld:pubmed |
| pubmed-article:2497094 | pubmed:author | pubmed-author:ThomasCC | lld:pubmed |
| pubmed-article:2497094 | pubmed:author | pubmed-author:MalaiseE PEP | lld:pubmed |
| pubmed-article:2497094 | pubmed:author | pubmed-author:GuichardMM | lld:pubmed |
| pubmed-article:2497094 | pubmed:author | pubmed-author:LartigauEE | lld:pubmed |
| pubmed-article:2497094 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2497094 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:2497094 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2497094 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2497094 | pubmed:pagination | 1157-60 | lld:pubmed |
| pubmed-article:2497094 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2497094 | pubmed:meshHeading | pubmed-meshheading:2497094-... | lld:pubmed |
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| pubmed-article:2497094 | pubmed:meshHeading | pubmed-meshheading:2497094-... | lld:pubmed |
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| pubmed-article:2497094 | pubmed:meshHeading | pubmed-meshheading:2497094-... | lld:pubmed |
| pubmed-article:2497094 | pubmed:meshHeading | pubmed-meshheading:2497094-... | lld:pubmed |
| pubmed-article:2497094 | pubmed:meshHeading | pubmed-meshheading:2497094-... | lld:pubmed |
| pubmed-article:2497094 | pubmed:meshHeading | pubmed-meshheading:2497094-... | lld:pubmed |
| pubmed-article:2497094 | pubmed:meshHeading | pubmed-meshheading:2497094-... | lld:pubmed |
| pubmed-article:2497094 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2497094 | pubmed:articleTitle | New high O2 carrying perfluorochemical emulsions and/or carbogen: reactions of a human tumor xenograft to irradiation. | lld:pubmed |
| pubmed-article:2497094 | pubmed:affiliation | Laboratoire de Radiobiologie Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France. | lld:pubmed |
| pubmed-article:2497094 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2497094 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2497094 | lld:pubmed |
