Linked Life Data

2497094

Source:http://linkedlifedata.com/resource/pubmed/id/2497094

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-6-19
pubmed:abstractText
The effects of two new perfluorochemical emulsions based on F-66E and PFOB which carry, in combination with carbogen, more oxygen than Fluosol-DA 20% were investigated on a human tumor xenograft (HRT18). Tumor bearing mice were pretreated with 15 ml/kg of F-66E emulsion (50 w/v%) or PFOB (100 w/v%) emulsion in the presence of carbogen for 1 hr prior to and during irradiation. F-66E emulsion was non toxic in vitro. In vivo, the dose modifying factor was 1.8 for mice pretreated with carbogen and F-66E emulsion whereas it was 1.6 for carbogen-breathing mice. Results with PFOB emulsion were similar to those obtained with F-66E emulsion. The effect of F-66E emulsion was studied using a fractionated radiation treatment: 12 Gy were delivered in 6 fractions of 2 Gy with an interval of 8 hrs between fractions. A single dose of F-66E emulsion was injected before the first irradiation. Surviving fractions were 0.35 for air-breathing mice, 0.091 for carbogen-breathing mice and 0.099 for carbogen-breathing mice pretreated with F-66E emulsion. These results showed that carbogen alone or carbogen plus F-66E or PFOB emulsion were very efficient even with low doses of radiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0360-3016
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1157-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
New high O2 carrying perfluorochemical emulsions and/or carbogen: reactions of a human tumor xenograft to irradiation.
pubmed:affiliation
Laboratoire de Radiobiologie Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't