| pubmed-article:2484023 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2484023 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2484023 | lifeskim:mentions | umls-concept:C0600251 | lld:lifeskim |
| pubmed-article:2484023 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:2484023 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:2484023 | lifeskim:mentions | umls-concept:C0001060 | lld:lifeskim |
| pubmed-article:2484023 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2484023 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:2484023 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2484023 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:2484023 | pubmed:dateCreated | 1990-7-12 | lld:pubmed |
| pubmed-article:2484023 | pubmed:abstractText | Human blood monocytes isolated by centrifugal elutriation from healthy donors were tested for ability to produce membrane-associated IL-1 in response to activation stimuli such as various types of interferons (alpha, beta and gamma) and/or synthetic des-methyl muramyl dipeptide (norMDP). When monocytes were treated with norMDP or lipopolysaccharide (LPS) for 16 hr, they released IL-1 into their culture supernatant. When these activated monocytes were fixed with paraformaldehyde (PFA), they stimulated blastogenic responses of C3H/HeJ mouse thymocytes to PHA, suggesting that membrane-associated IL-1 could be induced by norMDP or LPS. Membrane-associated IL-1 was also found to be induced by the synergistic actions of suboptimal concentrations of rIFN-gamma and nor MDP, but not of rIFN-alpha A or rIFN-beta with norMDP. A specific anti-IL-1 alpha antiserum completely inhibited membrane-associated IL-1 activity, but did not affect the thymocyte-stimulating activity of fixed monocytes. IL-1 alpha was detected by fluorescence staining using the anti-IL-1 alpha antiserum on monocytes fixed after gamma IFN-gamma and norMDP. These results suggest that IFN-gamma may be important in expression of membrane-bound IL-1 alpha by the human blood monocytes responsible for regulation of immune responses in vivo. | lld:pubmed |
| pubmed-article:2484023 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2484023 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2484023 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2484023 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2484023 | pubmed:issn | 0040-8875 | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:TanakaMM | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:NakanishiMM | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:YanagawaHH | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:MaedaKK | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:InamuraNN | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:NishiokaYY | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:SoneSS | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:OkuboAA | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:FukutaKK | lld:pubmed |
| pubmed-article:2484023 | pubmed:author | pubmed-author:YamashitaCC | lld:pubmed |
| pubmed-article:2484023 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2484023 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:2484023 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2484023 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:2484023 | pubmed:pagination | 97-105 | lld:pubmed |
| pubmed-article:2484023 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:meshHeading | pubmed-meshheading:2484023-... | lld:pubmed |
| pubmed-article:2484023 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2484023 | pubmed:articleTitle | Induction of membrane-associated interleukin 1 alpha (IL-1 alpha) by synergistic activation of human blood monocytes with interferon gamma and muramyl dipeptide analog. | lld:pubmed |
| pubmed-article:2484023 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2484023 | pubmed:publicationType | Comparative Study | lld:pubmed |
