| pubmed-article:2475353 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C0016976 | lld:lifeskim |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C0039241 | lld:lifeskim |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C0039945 | lld:lifeskim |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2475353 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2475353 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2475353 | pubmed:dateCreated | 1989-10-5 | lld:pubmed |
| pubmed-article:2475353 | pubmed:abstractText | Tachykinins produced a concentration-related contraction of the isolated guinea-pig gallbladder, with a rank order of potency neurokinin A (NKA) greater than Arg-neurokinin B = neurokinin B (NKB) greater than substance P (SP). Only the effect of SP was potentiated by thiorphan (0.1-10 microM). A significant enhancement of the response to SP was also produced by captopril (1 microM). [Nle10]NKA-(4-10) and [beta-Ala8]NKA-(4-10), selective NK-2 receptor agonists, were active, whereas [Pro9]SP sulfone (selective NK-1 agonist) was almost ineffective. [MePhe7]NKB (selective NK-3 agonist) had some activity but only at high concentrations. Septide was almost ineffective and DiMeC7 had an action comparable to that of [MePhe7]NKB. None of the effects induced by these synthetic tachykinin analogs were significantly potentiated by thiorphan. Capsaicin (10 microM) produced a contraction which was unaffected by thiorphan. Both capsaicin and NKA-induced contractions were antagonized by Spantide at concentrations (5-10 microM) which had no effect against the atropine-sensitive contractions produced by electrical field stimulation. Capsaicin (1 microM) produced a consistent release of SP-like immunoreactivity (SP-LI) and a second application of the drug had no further effect, indicating complete desensitization. SP-LI release by capsaicin was almost doubled in the presence of thiorphan. These findings indicate that NK-2 and possibly some NK-3 receptors mediate the contractile response of the guinea-pig gallbladder to tachykinins. Both exogenous and endogenous (released by capsaicin) SP were degraded to a significant extent in this organ via a thiorphan-sensitive mechanism, the identity of which remains to be established. | lld:pubmed |
| pubmed-article:2475353 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2475353 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2475353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2475353 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2475353 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2475353 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:RegoliDD | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:SurrentiCC | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:DrapeauGG | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:MeliAA | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:MaggiC ACA | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:SanticioliPP | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:PatacchiniRR | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:RenziDD | lld:pubmed |
| pubmed-article:2475353 | pubmed:author | pubmed-author:RoveroPP | lld:pubmed |
| pubmed-article:2475353 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2475353 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:2475353 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:2475353 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2475353 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2475353 | pubmed:pagination | 51-61 | lld:pubmed |
| pubmed-article:2475353 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
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| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
| pubmed-article:2475353 | pubmed:meshHeading | pubmed-meshheading:2475353-... | lld:pubmed |
| pubmed-article:2475353 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2475353 | pubmed:articleTitle | Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins. | lld:pubmed |
| pubmed-article:2475353 | pubmed:affiliation | Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy. | lld:pubmed |
| pubmed-article:2475353 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2475353 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2475353 | lld:pubmed |
