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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1989-5-11
|
| pubmed:abstractText |
Amlodipine, a new long-acting dihydropyridine calcium antagonist, was compared with placebo and atenolol in 125 patients with mild to moderate systemic hypertension [supine diastolic blood pressure (DBP) 90-114 mm Hg]. Patients received placebo for 4 weeks, followed by a random allocation to an 8-week double-blind, once-daily treatment with amlodipine (n = 41), atenolol (n = 43), or placebo (n = 41). The changes in 24-h post-dose blood pressure (BP) from baseline to final visit for amlodipine (mean daily dose 8.8 mg, range 5-10 mg) were -12.8 +/- 2.0/ -10.1 +/- 1.2 mm Hg in supine BP and -11.5 +/- 2.3/-9.8 +/- 1.1 mm Hg in standing BP (p less than 0.001); for atenolol (mean daily dose 83.7 mg, range 50-100 mg), the changes from baseline were -11.3 +/- 2.3/-11.7 +/- 1.3 mm Hg in supine BP and -13.3 +/- 3.1/-12.3 +/- 1.5 mm Hg in standing BP (p less than 0.001); for placebo, the changes from baseline were -0.9 +/- 2.8/-3.5 +/- 0.9 mm Hg in supine BP and -1.6 +/- -2.6/-4.0 +/- 1.0 mm Hg in standing BP. In the study, goal response was defined as a supine DBP of less than 90 mm Hg or its decrease by greater than or equal to 10 mm Hg. The response rates were similar for atenolol (65%) and amlodipine (61%). Both active therapies were significantly more effective than placebo. Heart rate was significantly lowered by atenolol only.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amlodipine,
http://linkedlifedata.com/resource/pubmed/chemical/Atenolol,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Nifedipine
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0160-2446
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12 Suppl 7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S103-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2467116-Adolescent,
pubmed-meshheading:2467116-Adult,
pubmed-meshheading:2467116-Aged,
pubmed-meshheading:2467116-Amlodipine,
pubmed-meshheading:2467116-Atenolol,
pubmed-meshheading:2467116-Blood Pressure,
pubmed-meshheading:2467116-Calcium Channel Blockers,
pubmed-meshheading:2467116-Clinical Trials as Topic,
pubmed-meshheading:2467116-Double-Blind Method,
pubmed-meshheading:2467116-Electrocardiography,
pubmed-meshheading:2467116-Female,
pubmed-meshheading:2467116-Heart Rate,
pubmed-meshheading:2467116-Humans,
pubmed-meshheading:2467116-Hypertension,
pubmed-meshheading:2467116-Lipids,
pubmed-meshheading:2467116-Male,
pubmed-meshheading:2467116-Middle Aged,
pubmed-meshheading:2467116-Nifedipine,
pubmed-meshheading:2467116-Patient Compliance,
pubmed-meshheading:2467116-Random Allocation
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
A randomized placebo-controlled comparison of amlodipine and atenolol in mild to moderate systemic hypertension.
|
| pubmed:affiliation |
Albert Einstein College of Medicine, Bronx, New York.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|