Linked Life Data

2460327

Source:http://linkedlifedata.com/resource/pubmed/id/2460327

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-12-9
pubmed:abstractText
Using an auditory 'oddball' paradigm and classical conditioning, we have studied auditory evoked potentials (AEPs) and P300-like potentials in monkeys pre- and post-MPTP treatment. Free-field acoustic stimuli were 500 Hz and 4000 Hz tones, which were designated as the 'frequent' and 'rare' conditions, respectively. The 4000 Hz stimuli were reinforced with mild somatosensory electrical stimulation. During the first few weeks following 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) administration, all monkeys gradually developed a parkinsonian syndrome, which partially, but not completely improved within 30-40 days in 2 animals. The amplitudes of the AEP were initially significantly decreased, but progressively returned to pretreatment magnitudes in the 2 monkeys which partially recovered. P300-like potentials were initially abolished in all animals; however, 30-40 days later P300 spontaneously re-emerged in the same 2 monkeys. Latencies of both of these signals were unaffected by MPTP. Acute administration of dopamine precursor during the first phase of neurotoxicity partially and temporarily improved depressed AEP amplitudes, but did not restore absent P300-like potentials. The relevance of these results for Parkinson's disease is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
461-8
pubmed:dateRevised
2008-9-9
pubmed:meshHeading
pubmed:articleTitle
Alterations in event-related potentials (ERPs) of MPTP-treated monkeys.
pubmed:affiliation
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't