Linked Life Data

2459579

Source:http://linkedlifedata.com/resource/pubmed/id/2459579

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1988-11-9
pubmed:abstractText
Differential normal pulse voltammetry (DNPV) using an electrochemically treated carbon fiber electrode was applied to the investigation of the in vivo changes in extracellular 5-hydroxyindoleacetic acid (5HIAA) in the B3 group of serotonin neurons during experimental manipulations of arterial pressure. Drug-induced hypertension (phenylephrine infusion) caused, during the infusion, an increase in extracellular 5HIAA concentration which continued to rise, reaching +100% 2 hours after stopping the infusion. In contrast, drug-induced hypotension (sodium nitroprusside infusion) was not associated with any change in extracellular 5HIAA during the infusion while the return to the initial arterial pressure caused a progressive increase in the electrochemical signal, reaching +50% one hour after stopping the infusion. These data show that the extracellular 5HIAA concentration is increased when the arterial pressure increases, a result which suggests that B3 serotonin neurons could have a vasodepressor role in the central regulation of arterial pressure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1031-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
In vivo voltammetry in the B3 group of serotonin neurons of the rat medulla oblongata after drug-induced modifications of arterial pressure.
pubmed:affiliation
Laboratoire de Neuropharmacologie, UA CNRS 1196, Faculté de Pharmacie, Lyon, France.
pubmed:publicationType
Journal Article