| pubmed-article:2451738 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C0034052 | lld:lifeskim |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:2451738 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:2451738 | pubmed:dateCreated | 1988-5-13 | lld:pubmed |
| pubmed-article:2451738 | pubmed:abstractText | 1. The release of [3H]noradrenaline ([3H]NA) from the isolated main pulmonary artery of the rabbit has been measured in the presence of neuronal (cocaine, 3 X 10(-5) M) and extraneuronal (corticosterone, 5 X 10(-5) M) uptake blockers. 2. K+ removal from the external medium increased the release of [3H]NA, an action transiently inhibited by Ca2+-free (+1 mM-EGTA) solution, i.e. after Ca2+ removal transmitter release was first abolished and then started to increase again after a delay lasting about 90-120 min. 3. Ca2+ readmission to arteries which had been kept in Ca2+- and 'K+-free' solution, markedly increased the [3H]NA release. The rate of transmitter release was dependent on the preceding perfusion period with 'K+-free' solution, being greater for longer exposure times. 4. When Ca2+ and K+ were readmitted together to K+-depleted and Na+-enriched preparations, the release of [3H]NA transiently increased. 5. If K+ was readmitted first, the subsequently applied Ca2+ was ineffective in producing transmitter release. 6. Different alkali metal ions (Rb+, Cs+ or Li+) were also readmitted as K+ substitutes together with Ca2+. In all cases the release of neurotransmitter transiently increased; however, the rate of release was dependent on the monovalent cation used. Thus, Rb+ ions were as effective as, Cs+ about one-third as effective as, and Li+ about one-fifth as effective as K+ in activating the Na+ pump. 7. It is concluded that in the absence of external Ca2+, and in response to Na+-pump inhibition, the release of Ca2+ from internal stores is responsible for the NA release observed. On readmission of Ca2+ the rate of transmitter release is dependent on the Na+ previously gained inside. Furthermore, the activity of the Na+ pump determines the rate of transmitter release through the Na-Ca exchange mechanism. | lld:pubmed |
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| pubmed-article:2451738 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2451738 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2451738 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2451738 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2451738 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2451738 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:2451738 | pubmed:author | pubmed-author:MagyarKK | lld:pubmed |
| pubmed-article:2451738 | pubmed:author | pubmed-author:TörökT LTL | lld:pubmed |
| pubmed-article:2451738 | pubmed:author | pubmed-author:NguyenT TTT | lld:pubmed |
| pubmed-article:2451738 | pubmed:author | pubmed-author:TóthP TPT | lld:pubmed |
| pubmed-article:2451738 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2451738 | pubmed:volume | 393 | lld:pubmed |
| pubmed-article:2451738 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2451738 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2451738 | pubmed:pagination | 29-42 | lld:pubmed |
| pubmed-article:2451738 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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| pubmed-article:2451738 | pubmed:meshHeading | pubmed-meshheading:2451738-... | lld:pubmed |
| pubmed-article:2451738 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2451738 | pubmed:articleTitle | [3H]noradrenaline release from rabbit pulmonary artery: sodium-pump-dependent sodium-calcium exchange. | lld:pubmed |
| pubmed-article:2451738 | pubmed:affiliation | Department of Pharmacodynamics, Semmelweis University of Medicine, Budapest, Hungary. | lld:pubmed |
| pubmed-article:2451738 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2451738 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2451738 | lld:pubmed |
