Linked Life Data

2438923

Source:http://linkedlifedata.com/resource/pubmed/id/2438923

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1987-7-23
pubmed:abstractText
The efficacy of pirmenol in suppressing ventricular premature complexes (VPCs) was assessed in 196 patients in a placebo-controlled, double-blind, multicenter study. At a daily dosage of 200 to 400 mg, pirmenol was effective in suppressing VPCs. In the double-blind phase of the trial, 60% of patients had at least a 70% reduction in VPC frequency and at least 70% of those patients who entered the open-label phase of the study continued to show at least a 70% reduction in VPC rate. Pirmenol was well tolerated by most patients; 66% of the patients treated with pirmenol in the double-blind phase had no adverse experiences. Of those who did have an adverse experience, the most common complaint was unusual taste. Serious adverse reactions were rare and only 2% of the patients had what may have been a proarrhythmic response. The same pattern of tolerance was seen in the open-label phase of the study when 151 patients were treated for an extended length of time with pirmenol. Pirmenol shows considerable promise for patients in whom the reduction of VPC frequency is desirable. Currently available antiarrhythmic drugs may have limited efficacy, cause serious or intolerable side effects or require frequent administration. Pirmenol has a convenient twice-daily dosing regimen, dependable antiarrhythmic action and a good safety record. This study demonstrated the effectiveness and safety of pirmenol in the control of VPCs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43H-47H
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
A multicenter dose-response study of pirmenol hydrochloride in patients with ventricular premature contractions.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial